Ancient Proteins Offer New Clues About the Origin of Life on Earth

The origin of life is a scientific mystery that has captivated researchers for centuries. While there are many theories about how life first arose on Earth, the exact process remains unknown.

Researchers have used laboratory simulations to recreate the conditions of early Earth and have discovered that the evolution of ancient proteins into all forms of life on the planet, including plants, animals, and humans, would not have been possible without specific

“You see the same amino acids in every organism, from humans to bacteria to archaea, and that’s because all things on Earth are connected through this tree of life that has an origin, an organism that was the ancestor to all living things,” said Stephen Fried, a Johns Hopkins chemist who co-led the research with scientists at Charles University in the Czech Republic. “We’re describing the events that shaped why that ancestor got the amino acids that it did.”

The findings are newly published in the Journal of the American Chemical Society.

In the lab, the researchers mimicked primordial protein synthesis of 4 billion years ago by using an alternative set of amino acids that were highly abundant before life arose on Earth.

They found ancient organic compounds integrated the amino acids best suited for protein folding into their biochemistry. In other words, life thrived on Earth not just because some amino acids were available and easy to make in ancient habitats but because some of them were especially good at helping proteins adopt specific shapes to perform crucial functions.

“Protein folding was basically allowing us to do evolution before there was even life on our planet,” Fried said. “You could have evolution before you had biology, you could have natural selection for the chemicals that are useful for life even before there was Ancient Proteins Offer New Clues About the Origin of Life on Earth